REVIEW ARTICLE ON MAGNETIC PARTICLE IMAGING (MPI)

Abstract

Due to concerns regarding the complications associated with gadolinium-based contrast agents (GBCAs) in MRI scans, the field of radiology is shifting towards safer options such as superparamagnetic iron oxide nanoparticles (SPIONs) and Magnetic Particle Imaging (MPI). MPI, an innovative tomographic technology, employs SPION tracers to achieve real-time, high-definition imaging without the use of ionizing radiation, thereby ensuring safety by operating at excitation frequencies below 25 kHz. The chemical and physical characteristics of MPI highlight its safety compared to other imaging modalities, utilizing the nonlinear magnetization curve of SPIONs for radiation-free imaging. Tracers like Resovist and Feraheme influence spatial resolution and signal intensity in MPI. Applications of MPI encompass effective cell tracking, promising advancements in vascular imaging, and potential uses in oncology and functional imaging. The assessment concludes that MPI is a low-risk approach, particularly benefiting patients with chronic kidney disease and those susceptible to iodinated contrast, with future directions focusing on refining techniques, creating more advanced nanoparticles, and broadening applications across various medical domains.